Antonia Morita Iswari Saktiawati, Kuwat Triyana, Siska Dian Wahyuningtias, Bintari Dwihardiani, Trisna Julian, Shidiq Nur Hidayat, Riris Andono Ahmad, Ari Probandari, Yodi Mahendradhata

https://doi.org/10.1371/journal.pone.0249689
Journal : PLOS One

Abstract

Even though conceptually, Tuberculosis (TB) is almost always curable, it is currently the world’s leading infectious killer. Patients with pulmonary TB are the source of transmission. Approximately 23% of the world’s population is believed to be latently infected with TB bacteria, and 5–15% of them will progress at any point in time to develop the disease. There was a global diagnostic gap of 2.9 million between notifications of new cases and the estimated number of incident cases, and Indonesia carries the third-highest of this gap. Therefore, screening TB among the community is of great importance to prevent further transmission and infection. The electronic nose for screening TB (eNose-TB) project is initiated in Yogyakarta, Indonesia, to screen TB by breath test with an electronic-nose that is easy-to-use, point-of-care, does not expose patients to radiation, and can be produced at low cost. read more

Abstract       It has been successfully synthesized silver nanoparticles by chemical reduction methods. Silver nitrate (AgNO3) is used as a metal precursor and trisodium citrate as a reducing agent with varying concentrations of the stabilizer PVA. The UV-Vis spectrometer shows that increasing the mass concentration of the stabilizer can sharpen the surface plasmon maximum absorption band and there is a shift in the maximum absorption band towards a larger wavelength. This shift occurred from a wavelength of 428.79 nm at a PVA concentration of 0.85 ppm shifted to a wavelength of 429.01 nm, 430.93 nm and 434.13 nm for each PVA concentration of 1.70 ppm, 2.55 ppm and 4.25 ppm. The observation results of the SPR phenomenon showed a shift in the SPR angle when a thin layer of silver as the active ingredient of the sensor was coated with silver nanoparticles. This addition also sharpens the reflectance value. The SPR angle shift and the increase in reflectance value are caused by changes in the surface plasmon wave constant, which becomes a reference that the SPR phenomenon by modifying the sensing surface using an additional layer of silver nanoparticles can increase its sensitivity. Pengarang : L Mahmudin, D Darwis, E Suharyadi, ABS Utomo, K Abraha